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Saturday, 21 December 2013

Applications of Uv-Vis Spectrophotometer

  • Structure elucidation of organic compounds
Location of peaks and combination of peaks, it can be concluded that whether the compound is saturated or unsaturated, hetero atoms are present or not etc.
  • Quantitative analysis
  • A = log I0 / It = log 1/ T = – log T = εbc 
  • Qualitative analysis
Can characterize those types of compounds which absorbs UV radiation. Identification is done by comparing the absorption spectrum with the spectra of known compounds.
UV absorption spectroscopy is generally used for characterizing aromatic compounds and aromatic olefins.
  •  Chemical kinetics
    Kinetics of reaction can also be studied using UV spectroscopy. The UV radiation is passed through the reaction cell and the absorbance changes can be observed.
  • Quantitative analysis of pharmaceutical substances
    Many drugs are either in the form of raw material or in the form of formulation. They can be assayed by making a suitable solution of the drug in a solvent and measuring the absorbance at specific wavelength.
  •  Molecular weight determination
    Molecular weights of compounds can be measured spectrophotometrically by preparing the suitable derivatives of these compounds.
  • As HPLC detector
A UV/Vis spectrophotometer may be used as a detector for HPLC. The presence of an analyte gives a response which can be assumed to be proportional to the concentration.
  • Detection of Impurities
 Perkin Elmer Uv-Vis

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